Copyright, 2023. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Things to remember when you fill your prescription. Modified-release nitrate preparations: use a once-daily dose to maintain a nitrate-low period and thus minimize tolerance. With any medication, there are risks and benefits. Real test is coronary angiography. My blood pressure, cholesterol and pulse are all normal and I have no chest pains, shortness of breath or other heart problem symptoms. It might help to take isosorbide mononitrate and dinitrate after meals. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks (chest pain). Prescribed for Angina, Anal Fissure and amlodipine, lisinopril, aspirin, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem. Follow directions about how much medicine to take. If you have recently had a head injury or a heart attack. you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. Lyrica and Metoclopramide drug interaction, Calcitriol and Metoclopramide drug interaction. Does isosorbide mononitrate (Monoket) lower blood pressure? Natural Medicines. This risk may be even higher for certain groups. Isosorbide Mononitrate (Oral Route) - Mayo Clinic tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Many common herbal supplements interact with common heart medicines. 8600 Rockville Pike Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Below is the list of medicines, which contains Isosorbide Mononitrate as ingredient. Isosorbide mononitrate works in two ways. Do not store in the bathroom. Usually avoid combinations; use it only under special circumstances. Mehta D. Botanical medicines. Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Isosorbide-5-mononitrate ISMN usually begins acting within 30 minutes and its effects last six to eight hours. What are the interactions of Isosorbide Mononitrate ? Mayo Clinic; 2021. 67% of reviewers reported a positive effect, while 13% reported a negative effect. The tablet usually is taken two or three times daily. Therefore, oral nitrates should not be used by patients who are sensitive to the effects of hypotension, such as those with pre-existing hypotension, shock, vascular collapse or significant cerebrovascular disease, significant anaemia or hypothyroidism. Integrative medicine (complementary and alternative medicine). Drug interactions may change how your medications work or increase your risk for serious side effects. Isosorbide dinitrate (Isordil): Basics, Side Effects & Reviews - GoodRx Liperoti R, et al. Do not stop taking it without consulting your doctor. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. . 1998 Oct;61(10):577-83. If you buy any medicines, please check with a pharmacist that they are suitable for you to take with isosorbide mononitrate. tell your doctor if you may be dehydrated, if you have recently had a heart attack, or if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles). Does isosorbide mononitrate (Monoket) affect your kidneys? Store it at room temperature and away from excess heat and moisture (not in the bathroom). You could also spray your face with cool water or sip non-alcoholic cold or iced drinks. Do infrared saunas have any health benefits? Last Revised - 09/15/2019. Please upgrade your browser or download modern browsers from here! it is a safe and effective alternative; the choice between beta blockers and calcium channel blockers depends . You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. https://naturalmedicines.therapeuticresearch.com. Discuss the risks and benefits with your doctor. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Generic alternatives may be available. Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). We comply with the HONcode standard for trustworthy health information. Limited data from animal studies indicate no adverse effects on the pregnancy or the unborn child. 41% of reviewers reported a positive effect, while 50% reported a negative effect. Eur Heart J. Isosorbide mononitrate systemic 60 mg (A ID). It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. Isosorbide mononitrate vs. Amlodipine besylate, Isosorbide mononitrate vs. Bisoprolol fumarate, Isosorbide mononitrate vs. Diltiazem hydrochloride, Isosorbide mononitrate vs. Isosorbide dinitrate, Isosorbide mononitrate vs. Metoprolol succinate, Isosorbide mononitrate vs. Metoprolol tartrate, Isosorbide mononitrate vs. Nitrolingual pumpspray, Isosorbide mononitrate and Aspirin (7,880 reports), Isosorbide mononitrate and Furosemide (6,020 reports), Isosorbide mononitrate and Amlodipine (3,554 reports), Isosorbide mononitrate and Simvastatin (3,508 reports), Isosorbide mononitrate and Omeprazole (3,422 reports), Isosorbide mononitrate and Lisinopril (3,099 reports), Isosorbide mononitrate and Metformin (2,822 reports), Isosorbide mononitrate and Carvedilol (2,589 reports), Isosorbide mononitrate and Clopidogrel (2,524 reports), Isosorbide mononitrate and Acetylsalicylic acid (2,355 reports). Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Isosorbide mononitrate is very similar to isosorbide dinitrate. Cardizem may also be used for purposes not listed in this medication guide. Isosorbide mononitrate - Wikipedia Once- versus twice-daily administration of controlled-release isosorbide-5-mononitrate 60 mg in the treatment of stable angina pectoris. Accessed Sept. 7, 2022. Do not let anyone else take your medication. The use of the Truven Health products is at your sole risk. Browse all drugs on eHealthMe. Manufacturer's PIL, Imdur 60 mg tablets; TopRidge Pharma Ltd, The electronic Medicines Compendium. Sept. 26, 2022. Patient does not provide medical advice, diagnosis or treatment. If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. the unsubscribe link in the e-mail. The herb licorice may lower warfarin levels and can add to digoxin's effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomachanxietyback painbelchingblemishes on the skinbloatedbreast painburning feeling in the chest or stomachburning, dry, or itching eyeschange in color visionchanges in visioncold sweatscongestionconstipationcontinuing ringing or buzzing or other unexplained noise in the earscough producing mucusdecreased interest in sexual intercoursedifficulty seeing at nightdifficulty with movingdischarge, excessive tearingdouble visiondrooping upper eyelidsdull ache or feeling of pressure or heaviness in the legsearacheexcess air or gas in the stomach or intestinesfeeling of constant movement of self or surroundingsfeeling of warmthfeeling unusually coldfrequent urge to defecatefrozen shoulderfull feelinghearing lossheartburnhyperventilationinability to have or keep an erectionincreased appetiteincreased sensitivity of the eyes to sunlightincreased sputumindigestionirritabilityitching skin near damaged veinslack or loss of strengthloss in sexual ability, desire, drive, or performancemuscle or bone painmuscle stiffness or weaknessnightmaresnoisy breathingpain or tenderness around the eyes and cheekbonespassing gaspimplespoor concentrationrashredness of the face, neck, arms, and occasionally, upper chestredness, pain, swelling of the eye, eyelid, or inner lining of the eyelidredness, swelling, or soreness of the tonguerestlessnessseeing doublesensation of spinningsleepiness or unusual drowsinesssmall clicking, bubbling, or rattling sounds in the lung when listening with a stethoscopesmall lumps under the skinsore mouth or tonguestiff neckstomach bloating, burning, cramping, or painstomach discomfort or upsetstraining while passing stoolstuffy nosesudden sweatingswollen feet and anklestender, swollen glands in the necktenderness in the stomach areaterrifying dreams causing sleep disturbancestooth disordertrouble swallowinguncontrolled twisting movements of the neckvoice changesweight losswhite patches in the mouth, tongue, or throatOther side effects not listed may also occur in some patients. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. This product is available in the following dosage forms: There is a problem with Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. isosorbide mononitrate (Rx) Brand and Other Names: Imdur, Monoket, more. If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia). Ask your pharmacist any questions you have about refilling your prescription. St. John's wort. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. What should I know regarding pregnancy, nursing and administering Isosorbide Mononitrate to children or the elderly? These side effects may go away during treatment as your body adjusts to the medicine. Nitrates (eg, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin). The extended-release tablet usually is taken once daily in the morning. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, List Isosorbide Mononitrate side effects by likelihood and severity. It works more slowly and lasts for about 12 hours, so you only need to take it once a day. [2] It can be used both to treat and to prevent heart-related chest pain; however, it is generally less preferred than beta blockers or calcium channel blockers. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction. This side-effect usually disappears after a few days, Do not drive and do not use tools or machines while affected, If either of these becomes troublesome, speak with your doctor. Isosorbide dinitrate (Isordil) is available as both a short-acting tablet and long-acting capsule. In: Textbook of Natural Medicine. Portions of this document last updated: Feb. 01, 2023. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Isosorbide extended-release (long-acting) tablets and extended-release capsules are used for the management of chest pain in people who have coronary artery disease. 72% of reviewers reported a positive effect, while 12% reported a negative effect. tell your doctor if you are taking or have recently taken riociguat (Adempas) or a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). This medicine is available only with your doctor's . May also be prescribed off label for Esophageal Spasm. This form of skin cancer is mostly caused by PhD (Pharmacology) Pursuing, M.Pharma (Pharmacology), B.Pharma - Certificate in Nutrition and Child Care, MBBS, Master in Healthcare Administration, Diploma in Occupational Health, What are the uses of Isosorbide Mononitrate. (1) Starting on a low dosage was associated with a reduced frequency and severity of headache and did not notably influence the beneficial effect on angina pectoris. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. Dated October 2016. Ginkgo. Herbal supplements and heart medicines may not mix - Mayo Clinic Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur:Less commonAbnormal heart soundabsence of or decrease in body movementarm, back, or jaw painblack, tarry stoolsbladder painbleeding after defecationbleeding gumsblood in the urine or stoolsblurred visionbody aches or painburning while urinatingburning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelingschest pain or discomfortchest tightness or heavinesschillscold sweatscoldsconfusionconvulsionscough or hoarsenessdecreased urinediarrheadifficult or labored breathingdifficult, burning, or painful urinationdilated neck veinsdizzinessdizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting positiondry mouthear congestionextra heartbeatsfaintingfast, slow, irregular, pounding, or racing heartbeat or pulsefever or chillsflu-like symptomsfrequent urge to urinatefrequent urinationgeneral feeling of discomfort or illnessheadacheheadache, severe and throbbingheart murmurincreased need to urinateincreased sweatingincreased thirstincreased volume of pale, dilute urineirregular breathingitching, pain, redness, or swelling on the legjoint pain, stiffness, or swellinglightheadednessloss of appetiteloss of voicelower back, side, or stomach painmuscle aches and painsmuscle crampsnasal congestionnausea or vomitingnervousnessnumbness or tingling in the hands, feet, or lipspain or discomfort in the arms, jaw, back, or neckpain, tension, and weakness upon walking that subsides during periods of restpartial or slight paralysispassing urine more oftenpinpoint red or purple spots on the skinpounding in the earsrunny noseshakiness in the legs, arms, hands, or feetshiveringsneezingsore on the legsore throatsudden decrease in the amount of urinesweatingswellingswelling of the face, fingers, feet, or lower legstightness in the chesttrembling or shaking of the hands or feettrouble sleepingtroubled breathinguncomfortable swelling around the anusunusual bleeding or bruisingunusual tiredness or weaknessvomiting of blood or material that looks like coffee groundsweaknessweight gainRareBluish-colored lips, fingernails, or palmsdark urinepale skinrapid heart rateGet emergency help immediately if any of the following symptoms of overdose occur:Symptoms of overdoseBlurred or loss of visionbulging soft spot on the head of an infantchange in consciousnesschange in the ability to see colors, especially blue or yellowcold, clammy skindisturbed color perceptiondouble visionfeeling of constant movement of self or surroundingshalos around lightsheadache, severe and throbbingloss of consciousnessnight blindnessoverbright appearance of lightsparalysissensation of spinningtunnel visionSome side effects may occur that usually do not need medical attention. Is isosorbide mononitrate (Monoket) the same as nitroglycerin (Nitrostat)? It is also important information to carry with you in case of emergencies. 2023 Lybrate, Inc. All rights reserved. We don't support your browser. Lifestyle changes such as dietary changes, exercise, and not smoking may help this drug work better. Is it safe to drive while on this medicine? https://naturalmedicines.therapeuticresearch.com. Licorice. isosorbide mononitrate (Imdur, Ismo, Monoket) - MedicineNet Isosorbide Mononitrate - Uses, Side Effects, Substitutes, Composition Isosorbide comes as a tablet, an extended-release (long-acting) tablet, and an extended-release capsule to take by mouth. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Patients were randomized to either 60 mg 5-ISMN once daily (od) for two weeks or to 30 mg 5-ISMN od for one week followed by 60 mg 5-ISMN od for one week. Zhonghua Yi Xue Za Zhi (Taipei). Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Highly clinically significant. Clin Res Cardiol. Isosorbide mononitrate dose and side-effects info | Patient include protected health information. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. Trapidil is as effective as isosorbide-dinitrate for treating stable angina pectoris: a multinational, multicenter, double-blind, randomized study. MBBS, MS - General Surgery, mch neuro surgery. The body tends to develop a tolerance (decreased sensitivity) to ISMN when it is used continuously over 24 hours. Keep this medication in the container it came in, tightly closed, and out of reach of children. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 46 ratings on Drugs.com. All rights reserved. Herbal supplements can strongly affect the body. All rights reserved. Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Change positions slowly until your body is used to the medication. 8.0 out of 10 from a total of Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Hawthorn. For details see our conditions. 19 are major, 174 are moderate, and 2 are minor. The list below does not include all possible drug interactions with isosorbide mononitrate (Monoket). It works and leaves the body quickly, so it needs to be taken twice a day. But only about 25% of people who take herbal supplements tell their health care providers. Bethesda, MD 20894, Web Policies View more. There may be variations in CSA schedules between individual states. View World Anti-Doping Agency classifications, Prevention of Thromboembolism in Atrial Fibrillation, Prosthetic Heart Valves - Thrombosis Prophylaxis, Prosthetic Heart Valves - Mechanical Valves - Thrombosis Prophylaxis, Revascularization Procedures - Prophylaxis. 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (in Cafergot, in Migergot), methylergonovine (Methergine), methysergide (Sansert; no longer available in the U.S.), and pergolide (Permax; no longer available in the U.S.); medications for high blood pressure, heart failure, or an irregular heartbeat. Sildenafil ( Viagra ), tadalafil ( Cialis ), avanafil ( Stendra ),and vardenafil ( Levitra) increase the blood pressure lowering effects of isosorbide mononitrate and may cause excessive reductions in blood pressure. Isosorbide mononitrate should not be used in patients with severe anaemia, severe hypotension, closed angle glaucoma or severe hypovolaemia.Isosorbide mononitrate may give rise to postural hypotension and syncope in some patients. Isosorbide mononitrate is used to prevent chest pain ( angina) in patients with a certain heart condition ( coronary artery disease ). Imdur, Monoket (isosorbide mononitrate) dosing, indications - Medscape This content does not have an Arabic version. Isosorbide mononitrate. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed. Get emergency help immediately if any of the following symptoms of overdose occur: bulging soft spot on the head of an infant, change in the ability to see colors, especially blue or yellow, feeling of constant movement of self or surroundings. To avoid this problem, get up slowly, resting your feet on the floor for a few minutes before standing up. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. Copyright 2023 IBM Watson Health. Let your provider know if they are excessive. DUMQOL (DUtch Mononitrate Quality of Life) Study Group. May also be prescribed off label for Esophageal Spasm. Mayo Clinic. Swallow the tablet/capsule whole - do not chew or crush it before you swallow. Mehta D. Herbal & dietary supplements. This should pass after a few days. Natural Medicines. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). The longer you take isosorbide mononitrate, the more your body can become used to it (called tolerance), and then it can have less of an effect.